3D In Vitro Brain Modeling
Compared with the in vitro cell model, the in vitro 3D model in the stroke environment is closer to the human stroke environment and can meet the purpose of disease modeling and high-throughput screening. Therefore, the in vitro 3D model has unique advantages in stroke research. In addition, it was found that 3D brain-like organs derived from human pluripotent stem cells overcame the limitations of stem cell - based transplantation therapy to a certain extent, and showed many advantages, including abundant cell types, wide cell sources, a large number of cells, controllable cell differentiation and a certain tissue volume. In view of the important role of in vitro 3D stroke models in the study of the pathological development of stroke and the development of stroke therapies, Ace Neuroscience provides comprehensive technical services to promote the progress of in vitro 3D stroke model-based research.

Brain Organoid Modeling
There are two methods of brain organoid culture based on the orientation of differentiation. One is the organoid structure formed by stem cells during differentiation, which is independent of exogenous morphogenetic factors and contains multiple brain regions. The other is to add exogenous morphogenetic factors and neurotrophic factors at a specific time according to the regulatory mechanism of the human brain development process, so as to cultivate specific brain organoids. Ace Neuroscience has developed sophisticated solutions for both approaches, making it possible to develop brain organ models suitable for stroke research to advance the understanding of stroke pathologies and develop stroke therapies.

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